CMA 12 Microdialysis Probes

CMA 12 Microdialysis Probes

The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.

  • Optimized for CNS use
  • Ideal for chronic implantation
  • Available membrane: PAES, 20kDA MWCO or PES, 100 kDA MWCO
  • Membrane lengths: 1, 2, 3 or 4 mm
  • Membrane diameter: 0.5 mm
  • Available metal free

Item Listing

Item#DescriptionPriceQuantity
CMA8010431CMA 12 Elite Probe - 1 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8010432CMA 12 Elite Probe - 2 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8010433CMA 12 Elite Probe - 3 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8010434CMA 12 Elite Probe - 4 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8309661CMA 12 HighCO Probe - 1 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8309662CMA 12 HighCO Probe - 2 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8309663CMA 12 HighCO Probe - 3 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8309664CMA 12 HighCO Probe - 4 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011201CMA 12 Elite Metal Free Probe -1 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011202CMA 12 Elite Metal Free Probe - 2 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011203CMA 12 Elite Metal Free Probe - 3 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011204CMA 12 Elite Metal Free Probe - 4 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011221CMA 12 HighCO Metal Free Probe - 1 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011222CMA 12 HighCO Metal Free Probe - 2 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011223CMA 12 HighCO Metal Free Probe - 3 mm (pkg. of 3)Request a QuoteRequest a Quote
CMA8011224CMA 12 HighCO Metal Free Probe - 4 mm (pkg. of 3)Request a QuoteRequest a Quote

Full Description

The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.

A semi-permeable membrane is glued between the tip of the inner steel cannnula and the outer steel shaft. The perfusion fluid enters the membrane space through two holes in the inner cannula and flows into the shaft to the outlet.

All metal parts are treated to prevent oxidation of labile compounds in the perfusate. The membrane is available in both 20 000 and 100 000 Daltons cut-off as standard. The inlet/outlet capillaries are mounted in a blue plastic body matched to the size of a corresponding CMA 12 guide cannula.

Once implanted, the probe sits tightly in the guide cannula´s capsule without the need for screwing or cementing. FEP tubing can be connected to the probe using tubing adaptors. The CMA 12 Microdialysis Probes are guaranteed for single use, however, with proper care, they may be reused several times. Complete instructions are included.

Specifications

SpecificationsCMA8010431CMA8010432CMA8010433CMA8010434CMA8309661CMA8309662CMA8309663CMA8309664
Membrane Length1 mm2 mm3 mm4 mm1 mm2 mm3 mm4 mm
Membrane O D0.5 mm0.5 mm0.5 mm0.5 mm0.5 mm0.5 mm0.5 mm0.5 mm
Membrane MaterialPAESPAESPAESPAESPESPESPESPES
Molecular Weight Cut-off20 kDA MWCO20 kDA MWCO20 kDA MWCO20 kDA MWCO100 kDA MWCO100 kDA MWCO100 kDA MWCO100 kDA MWCO
Shaft Diameter0.64 mm0.64 mm0.64 mm0.64 mm0.64 mm0.64 mm0.64 mm0.64 mm
Shaft Length Metric14 mm14 mm14 mm14 mm14 mm14 mm14 mm14 mm
Intlet Internal Volumenegligiblenegligiblenegligiblenegligiblenegligiblenegligiblenegligiblenegligible
Outlet Internal Volume0.3 µL0.3 µL0.3 µL0.3 µL0.3 µ0.3 µ0.3 µ0.3 µ
ModelStandardStandardStandardStandardStandardStandardStandardStandard

Journal Articles

Gottås A, Ripel Å, Boix F, Vindenes V, Mørland J, Øiestad EL. (2015 ) Determination of dopamine concentrations in brain extracellular fluid using microdialysis with short sampling intervals, analyzed by ultra high performance liquid chromatography ta J Pharmacol Toxicol Methods.

Selected Recent Publications

Paasonen, J. et al., 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. Neuropharmacology, 119, pp.15–25.

Kealy, J. et al., 2017. Real-time changes in hippocampal energy demands during a spatial working memory task. Behavioural Brain Research, 326, pp.59–68.

Alves, I.A. et al., 2017. Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis. Antimicrobial Agents and Chemotherapy, p.AAC.00321-17.

Jin, W.-S. et al., 2017. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathologica, pp.1–14.

Kurosawa, T. et al., 2017. Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. Journal of Pharmaceutical Sciences, 0(0). Available at: http://jpharmsci.org/article/S0022-3549(17)30267-8... [Accessed May 14, 2017].

Bank, J.H.H. et al., 2017. Gene expression analysis and microdialysis suggest hypothalamic triiodothyronine (T3) gates daily torpor in Djungarian hamsters (Phodopus sungorus). Journal of Comparative Physiology B, pp.1–12.

Miller, S. et al., 2017. Therapeutic Uses Of Compounds Having Affinity To The Serotonin Transporter, Serotonin Receptors and Noradrenalin Transporter. Available at: http://www.freepatentsonline.com/y2017/0087138.html [Accessed May 14, 2017].

Wang, W. et al., 2017. Effect of Efflux Transporter Inhibition on the Distribution of Fluconazole in the Rat Brain. Neurochemical Research, pp.1–8.

Mørk, A. et al., 2017. Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex. European Journal of Pharmacology, 799, pp.1–6.

Takeda, A. et al., 2017. Characteristic of Extracellular Zn2+ Influx in the Middle-Aged Dentate Gyrus and Its Involvement in Attenuation of LTP. Molecular Neurobiology, pp.1–11.